Short Report Substantial Variation in qPCR Measured Mean Blood Telomere Lengths in Young Men from Eleven European Countries
نویسندگان
چکیده
DAN T.A. EISENBERG,* KLELIA D. SALPEA, CHRISTOPHERW. KUZAWA, M. GEOFFREY HAYES, AND STEVE E. HUMPHRIES ON BEHALF OF THE EUROPEAN ATHEROSCLEROSIS RESEARCH STUDY II GROUP Department of Anthropology, Northwestern University, Evanston, Illinois Cells 2 Society: The Center for Social Disparities and Health, Institute for Policy Research, Northwestern University, Evanston, Illinois Centre for Cardiovascular Genetics, Department of Medicine, Royal Free and University College Medical School, London, United Kingdom Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Medical School, Chicago, Illinois Center for Genetic Medicine, Northwestern University, Chicago, Illinois See Online Supplement 1 for list of EARS II Collaborators
منابع مشابه
Substantial variation in qPCR measured mean blood telomere lengths in young men from eleven European countries.
OBJECTIVES Telomeres, repetitive DNA sequences found at the ends of chromosomes, shorten with age in proliferating human tissues and are implicated in senescence. Previous studies suggest that shorter telomeres impair immune and cardiovascular function and result in increased mortality. Although few, prior studies have documented ethnic/population differences in human telomere lengths. The natu...
متن کاملResponse to: Reliability and validity of telomere length measurements.
length varies by DNA extraction method: implications for epidemiologic research. Cancer Epidemiol Biomarkers Prev 2013;22: 2047-54. 24. Hofmann JN, Hutchinson AA, Cawthon R et al. Telomere length varies by DNA extraction method: implications for epidemiologic research letter. Cancer Epidemiol Biomarkers Prev 2014;23:1129-30. 25. Denham J, Marques F, Charchar F. Leukocyte telomere length variati...
متن کاملThe effect of high intensity interval training on telomere length and telomerase activity in non-athlete young men
Introduction: Telomeres are DNA portions that are located on the two ends of the chromosome. Telomeres play an important role in cellular life. Exercise is one of the factors that contributes to their control. The purpose of the present study was to investigate the effect of 8 weeks of high intensity interval training (HIIT) on telomere length and telomerase activity in non-athletic young men. ...
متن کاملAge-Related Declines and Disease-Associated Variation in Immune Cell Telomere Length in a Wild Mammal
Immunosenescence, the deterioration of immune system capability with age, may play a key role in mediating age-related declines in whole-organism performance, but the mechanisms that underpin immunosenescence are poorly understood. Biomedical research on humans and laboratory models has documented age and disease related declines in the telomere lengths of leukocytes ('immune cells'), stimulati...
متن کاملTelomere length measurement by a novel monochrome multiplex quantitative PCR method
The current quantitative polymerase chain reaction (QPCR) assay of telomere length measures telomere (T) signals in experimental DNA samples in one set of reaction wells, and single copy gene (S) signals in separate wells, in comparison to a reference DNA, to yield relative T/S ratios that are proportional to average telomere length. Multiplexing this assay is desirable, because variation in th...
متن کامل